Metastatic pulmonary calcinosis and leukocytoclastic vasculitis in a patient with multiple myeloma.

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Cagirgani S., Soyer N. , Vural F. , Saydam G. , Simsir I. , Donmez A., ...More

Turkish journal of haematology : official journal of Turkish Society of Haematology, vol.29, no.4, pp.397-400, 2012 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5505/tjh.2012.23600
  • Title of Journal : Turkish journal of haematology : official journal of Turkish Society of Haematology
  • Page Numbers: pp.397-400


Both leukocytoclastic vasculitis and metastatic pulmonary calcification are conditions that rarely occur during the course of multiple myeloma. We present a multiple myeloma patient that had severe dyspnea due to metastatic pulmonary calcinosis, and ulceronecrotic skin lesions caused by leukocytoclastic vasculitis. After 3 courses of standard-dose chemotherapy all skin and pulmonary lesions disappeared. Autologous peripheral stem cell transplantation was performed and during 1 year of follow-up the patient was in complete remission; after 1 year, laboratory test results indicated disease relapse. Although the patient was treated with bortezomib and dexamethasone, the disease progressed. Non-myeloablative allogeneic stem cell transplantation was performed, but despite of all treatment the patient died due to disease progression.