Therapeutic concentrations of tacrolimus do not interfere with endothelial nitric oxide synthesis in rat thoracic aortas and coronary arteries

Can, CENK; Erol, AYŞE; ÇINAR, Mehtap; Olukman, MURAT; Uelker, Sibel; Evinc, Akguen

doi:10.1097/fjc.0b013e31811faa8a

Therapeutic concentrations of tacrolimus do not interfere with endothelial nitric oxide synthesis in rat thoracic aortas and coronary arteries

Can C. , Erol A. , ÇINAR M., Olukman M. , Uelker S., Evinc A.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol.50, no.4, pp.399-405, 2007 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 50 Issue: 4
Publication Date: 2007
Doi Number: 10.1097/fjc.0b013e31811faa8a
Title of Journal : JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Page Numbers: pp.399-405

Abstract

This study aimed to investigate the potential effect of in vivo administration of immunosuppressive agent FK-506 (tacrolimus) on the endothelial function of rat thoracic aortas with respect to nitric oxide (NO) synthesis. In vitro effect of the drug on NO synthesis in cultured rat coronary microvascular endothelial cells (CMEC) was also studied.