Therapeutic concentrations of tacrolimus do not interfere with endothelial nitric oxide synthesis in rat thoracic aortas and coronary arteries

Can, CENK; Erol, AYŞE; ÇINAR, Mehtap; Olukman, MURAT; Uelker, Sibel; Evinc, Akguen

doi:10.1097/fjc.0b013e31811faa8a

Therapeutic concentrations of tacrolimus do not interfere with endothelial nitric oxide synthesis in rat thoracic aortas and coronary arteries

Atıf İçin Kopyala

Can C. , Erol A. , ÇINAR M., Olukman M. , Uelker S., Evinc A.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, cilt.50, ss.399-405, 2007 (SCI İndekslerine Giren Dergi)

Cilt numarası: 50 Konu: 4
Basım Tarihi: 2007
Doi Numarası: 10.1097/fjc.0b013e31811faa8a
Dergi Adı: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Sayfa Sayıları: ss.399-405

Özet

This study aimed to investigate the potential effect of in vivo administration of immunosuppressive agent FK-506 (tacrolimus) on the endothelial function of rat thoracic aortas with respect to nitric oxide (NO) synthesis. In vitro effect of the drug on NO synthesis in cultured rat coronary microvascular endothelial cells (CMEC) was also studied.