Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma


ZEYREK D., DEMİR E. , Alpman A., Ozkinay F. F. , GÜLEN F. , TANAÇ R.

ALLERGY AND ASTHMA PROCEEDINGS, cilt.29, ss.468-474, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 29 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2500/aap.2008.29.3154
  • Dergi Adı: ALLERGY AND ASTHMA PROCEEDINGS
  • Sayfa Sayıları: ss.468-474

Özet

Asthma is a complex genetic disease. Genetic and functional characteristics of intcrleukin (IL)-1 support a role as all asthma locus for the IL-1 family on chromosome 2q12-21. This study was performed to investigate the relationship between polymorphisms of IL-1beta promoter region -511C/T and IL-1. receptor antagonist IL-1Ra) gene (IL-RN) and bronchial asthma in Turkish children. Children were divided into two groups: (1) bronchial asthma (n = 328) and (2) healthy control (n = 246). Polymerase chain reaction was used to resolve the IL-1beta -511C/T and the IL-1Ra intron 2 polymorphisms. Plasma IgE concentrations were measured by immunoassays, and skin-prick tests were done in children with atopic diseases. The number of genotype CC and C allele in the control groups in IL-1beta -511C/T polymorphisms increased. The number of genotype 1/1 in the asthma groups and genotypes 112 and 515 and 5 allele in the control groups in IL-1Ra intron 2 gene polymorphism increased. Serum splgE level increased in the 212 genotype in the asthma groups in IL-1Ra intron 2 gene polymorphism. Based oil these results, we conclude that there Was an association of pediatric asthma with the IL-1beta -511C/T and IL-1Ra intron 2 gene polymorphism. Based on these findings, it has been proposed that IL-1beta -511C/T and IL-Ra intron 2 gene polymorphism are useful markers for prediction of asthma.