A novel theranostic nanobioconjugate: I-125/131 labeled phenylalanine conjugated boron nitride nanotubes


Guldu O. K. , Unak P. , Timur S.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.311, ss.1751-1762, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 311 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s10967-016-5127-4
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.1751-1762

Özet

Here we report the synthesis of boron nitride nanotubes (BNNTs) via a chemical vapor deposition method, as potential agents for boron neutron capture therapy. BNNTs were functionalized with PAMAM[G-2] dendrimer and then, conjugated with L-Phe using EDC/NHS. After that, BNNTs were radiolabeled with I-125/131, which are commonly used for both therapy and diagnosis in clinical and pre-clinical studies. BNNTs were radiolabeled with a maximum yield with I-125/131 in compared with 4-borono-L-phenyalanine which is currently used as a commercial drug. Radiolabeling parameters were optimized with thin layer radiochromatography and high performance liquid radiochromatography. BNNTs are promising nanobioconjugates as new theranostic agents.