The effects of calcium channel blockers are not related to their chemical structure in the collar model of the rabbit


YASA M. , Kerry Z. , REEL B. , ANACAK G. , ERTUNA E. , OZER A.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.35, no.1, pp.59-71, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1177/147323000703500106
  • Title of Journal : JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Page Numbers: pp.59-71

Abstract

Placing a silicone collar around the rabbit carotid artery induces intimal thickening, an early stage in atherosclerosis and restenosis. We investigated whether treatment with oral pranidipine, a new potent, long lasting dihydropyridine calcium channel blocker (CCB), inhibited collar-induced intimal thickening in addition to the changes in vascular reactivity usually observed in this model. Pranidipine treatment did not inhibit collar-induced intimal thickening. Placing the collar around the carotid artery resulted in the characteristic changes in vascular reactivity, such as increased sensitivity to 5-hydroxytryptamine. Treatment with N-omega-nitro-L-arginine (100 mu M) and pranidipine, however, did not affect collarinduced changes in vascular reactivity. From results of this and previous studies, we conclude that pranidipine does not prevent collar-induced intimal thickening or collar-induced changes in vascular reactivity. Not all CCBs prevent collarinduced intimal thickening, suggesting that the effects of these agents are not related to their chemical structure and/or their calcium channel-blocking actions.