Reversal of doxorubicin-induced vascular dysfunction by resveratrol in rat thoracic aorta: Is there a possible role of nitric oxide synthase inhibition?

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Olukman M. , Can C. , Erol A. , Öktem G. , Oral O. , Cınar M. G.

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.9, no.4, pp.260-266, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 4
  • Publication Date: 2009
  • Title of Journal : ANATOLIAN JOURNAL OF CARDIOLOGY
  • Page Numbers: pp.260-266
  • Keywords: Doxorubicin, vascular endothelial function, nitric oxide, resveratrol, rat, RED WINE, ADRIAMYCIN, PROTECTS

Abstract

Objective: The natural antioxidant, resveratrol has been suggested to protect against doxorubicin-induced cardiotoxicity. Although derangements in nitric oxide (NO) synthesis contribute to vascular endothelial dysfunction caused by doxorubicin, the effects of resveratrol on these parameters have not been evaluated yet. We investigated the impact of resveratrol on doxorubicin-induced vascular dysfunction in rat thoracic aorta with regard to NO synthesis in an experimental, prospective, controlled study.