Evaluation of the antinociceptive and anti-inflammatory activities of Satureja thymbra L. essential oil

Karabay-Yavasoglu N. Ü. , Baykan S., Ozturk B. , APAYDIN S., TUGLULAR I.

PHARMACEUTICAL BIOLOGY, vol.44, no.8, pp.585-591, 2006 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1080/13880200600896827
  • Page Numbers: pp.585-591


The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of the essential oil of Satureja thymbra L. (Lamiaceae). Antinociceptive activity of the essential oil was measured by the formalin test in mice and by the light tail-flick and hot-plate methods in rats. The paw-edema test was performed in rats to evaluate the anti-inflammatory effect of the essential oil. Motor coordination was assessed with a rotarod apparatus. Although the essential oil produced an antinociceptive effect during both the early (50 and 100 mg kg(-1)) and late phases (25, 50, and 100 mg kg(-1)) of the formalin test, it did not exert any significant antinociceptive and anti-inflammatory effects in tail-flick and paw-edema tests, respectively. In addition, a significant antinociceptive effect was detected in the hot-plate test (100 and 200 mg kg(-1)). No significant change was detected in sensory motor performance. In conclusion, S. thymbra L. essential oil does not exert any anti-inflammatory effect while it may have central analgesic activity in mice and rats.