TPH1 A218 allele is associated with suicidal behavior in Turkish population


beden o. , ŞENOL E. , ATAY S. , AK H. , ALTINTOPRAK A. E. , KIYAN G. S. , ...Daha Fazla

LEGAL MEDICINE, cilt.21, ss.15-18, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Serotonergic dysfunction is implicated in depression, psychiatric disorders and suicidal behaviors. The first and rate-limiting step in the synthesis of serotonin is catalyzed by tryptophan hydroxylase (TPH) which is encoded by TPH1 and THP2 genes. Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations.