Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis


Korkmaz C., Korkmaz K. S. , Manola J., Xi Z., Risberg B., Danielsen H., ...Daha Fazla

JOURNAL OF UROLOGY, cilt.172, ss.1134-1139, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Purpose: NKX3.1 is an androgen regulated gene that is largely specific to the prostate for expression and it is predicted to encode a homeobox protein. Null alleles of NKX3.1 in mice results in impaired prostate development as well as hyperplasia and dysplasia of the prostate. In addition, the NKX3.1 gene maps to a region of high loss of heterozygosity in prostate cancer in humans, suggesting that NKX3.1 might have a direct role in prostate carcinogenesis, possibly functioning as a tumor suppressor protein. Previous studies of the levels of NKX3.1 mRNA or protein in prostate cancer specimens have resulted in conflicting findings.