A second Middle Eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9


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LEAL S., Apaydin F. , BARNWELL C., IBER M., KANDOGAN T., PFISTER M., et al.

EUROPEAN JOURNAL OF HUMAN GENETICS, cilt.6, ss.341-344, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 6 Konu: 4
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1038/sj.ejhg.5200201
  • Dergi Adı: EUROPEAN JOURNAL OF HUMAN GENETICS
  • Sayfa Sayısı: ss.341-344

Özet

A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM).