Multiwalled Carbon Nanotubes-Chitosan Modified Single-Use Biosensors for Electrochemical Monitoring of Drug-DNA Interactions


SENGİZ C., CONGUR G., EKŞİN E., Erdem A.

ELECTROANALYSIS, vol.27, no.8, pp.1855-1863, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1002/elan.201500107
  • Title of Journal : ELECTROANALYSIS
  • Page Numbers: pp.1855-1863

Abstract

A multiwalled carbon nanotubes (CNT)-chitosan (CHIT) modified pencil graphite electrode (CNT-CHIT/PGE) was developed for the first time herein for electrochemical monitoring of the interaction of an anticancer drug, mitomycin C (MC) and DNA. The characterization of unmodified PGE, CHIT/PGE, CNT/PGE and CHIT-CNT/PGE were performed by scanning electron microscopy and cyclic voltammetry techniques. The oxidation signals of MC and guanine were measured before and after interaction at the surface of CNT-CHIT/PGEs using differential pulse voltammetry. Electrochemical impedance spectroscopy technique was also successfully utilized for monitoring of the interaction process at the surface of CNT-CHIT/PGEs in different interaction times.