miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic myeloid leukemia cells

Firatligil B., Avci C. B. , Baran Y.

JOURNAL OF BUON, vol.18, no.2, pp.437-441, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2013
  • Title of Journal : JOURNAL OF BUON
  • Page Numbers: pp.437-441
  • Keywords: chronic myeloid leukemia, dasatinib, drug resistance, imatinib, miR-17, nilotinib, RT-PCR, MICRORNAS, EXPRESSION, QUANTIFICATION, ONCOMIRS


Purpose: In this study we examined the expression levels of miR-17 which possesses oncogenic activities through downregulation of CDKN1A, p21 and E2F1 tumor suppressor genes, in imatinib sensitive and resistant chronic myeloid leukemia (CML) cells. On the other hand, we also determined the expression levels of miR-17 in response to tyrosine kinase inhibitors imatinib, nilotinib and dasatinib used for the treatment of CML.