Epidermal growth factor regulates apoptosis and oxidative stress in a rat model of spinal cord injury


Creative Commons License

Öztürk A. M. , Sozbılen M. C. , Sevgılı E., Dağcı T. , Ozyalcın H., Armagan G.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.49, no.6, pp.1038-1045, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1016/j.injury.2018.03.021
  • Title of Journal : INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Page Numbers: pp.1038-1045
  • Keywords: Spinal cord injury, Epidermal growth factor, Apoptosis, Antioxidants mechanisms, Antioxidant enzymes, IMPROVES MYELINATION, FUNCTIONAL RECOVERY, CELL-DEATH, IN-VIVO, EXPRESSION, DAMAGE, BRAIN, BAX, PROLIFERATION, REGENERATION

Abstract

Spinal cord injury (SCI) leads to vascular damage and disruption of blood-spinal cord barrier which participates in secondary nerve injury. Epidermal growth factor (EGF) is an endogenous protein which regulates cell proliferation, growth and differention. Previous studies reported that EGF exerts neuroprotective effect in spinal cord after SCI. However, the molecular mechanisms underlying EGFmediated protection in different regions of nervous system have not shown yet. In this study, we aimed to examine possible anti-apoptotic and protective roles of EGF not only in spinal cord but also in brain following SCI.