Magnetic nanoparticle-conjugated and radioiodinated-DESG: in vitro and in vivo efficiency investigation

YILMAZ T., ÜNAK P. , Muftuler F. Z. B. , MEDİNE E. İ. , İÇHEDEF Ç. , Kilcar A. Y.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.303, ss.63-69, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 303 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10967-014-3329-1
  • Sayfa Sayısı: ss.63-69


The purpose of this work is to combine magnetite nanoparticles with radioiodinated diethylstilbestrol-glucuronide (DESG) to get a prostate cancer agent. Magnetically targeted drug delivery by particulate carriers is an efficient method of delivering drugs to localized and targeted disease sites, such as tumors. Estrogen glucuronide derivative; DESG was synthesized which is specific for beta glucuronidase enzyme consisting tumor cells and conjugated with iron oxide nanoparticles (NP) and radioiodinated with I-125/131 to evaluate in vitro/in vivo radiopharmaceutical potential of NP conjugated DESG (NP-DESG) and magnetic field applied NP-DESG (MNP-DESG). According to cell culture studies, incorporation ratios of MNP-DESG were higher in MCF7 cells than A549 and Caco2 cells. Biodistribution experiments were verified that the range of the breast/blood and breast/muscle ratios was approximately between 1.82 and 10.10 in 240 min for ER unsaturated studies. The results are promising for targeted therapy of both estrogen receptor and enzyme beta-glucuronidase rich cancers.