Gingival Crevicular Fluid and Plasma Levels of Transglutaminase-2 and Oxidative Stress Markers in Cyclosporin A-Induced Gingival Overgrowth


BECERİK S. , CELEC P., GÜRKAN A. , Ozturk V. O. , KAMODYOVA N., Atilla G. , ...More

JOURNAL OF PERIODONTOLOGY, vol.87, no.12, pp.1508-1516, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 12
  • Publication Date: 2016
  • Doi Number: 10.1902/jop.2016.160031
  • Title of Journal : JOURNAL OF PERIODONTOLOGY
  • Page Numbers: pp.1508-1516
  • Keywords: Cyclosporine, gingival crevicular fluid, gingival overgrowth, oxidative stress, plasma, transglutaminase 2, LIPID-PEROXIDATION LEVELS, TOTAL OXIDANT STATUS, TISSUE TRANSGLUTAMINASE, CHRONIC PERIODONTITIS, MATRIX METALLOPROTEINASES, RENAL-TRANSPLANTATION, ANTIOXIDANT CAPACITY, REACTIVE OXYGEN, UP-REGULATION, IN-VIVO

Abstract

Background: Transglutaminase (TGM)-2 has been shown to contribute to fibrosis by extracellular matrix accumulation in some organs and is activated by intracellular reactive oxygen species. The aim of this study is to investigate levels of gingival crevicular fluid (GCF) and plasma TGM-2 and oxidative stress markers (OSMs) in cyclosporin A (CsA)-induced gingival overgrowth (GO).