SUSTAINED-RELEASE DOSAGE FORM OF PHENYLPROPANOLAMINE HYDROCHLORIDE .1. MICROENCAPSULATION AND IN-VITRO RELEASE KINETICS


SEVGI F., OZYAZICI M. , GUNERI T.

JOURNAL OF MICROENCAPSULATION, vol.11, no.3, pp.327-334, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 1994
  • Doi Number: 10.3109/02652049409040462
  • Title of Journal : JOURNAL OF MICROENCAPSULATION
  • Page Numbers: pp.327-334

Abstract

Microcapsules of phenylpropanolamine hydrochloride with core: wall ratios of 1:1, 2:1 and 1:2 were prepared by the coacervation-phase separation method, using ethylcellulose as the coating material. Two batches of PPA.HCl powder with different particle sizes ( > 58 mum and < 28 mum) were used as the core material. The different sizes of microcapsules were separated using a range of standard sieves (840-247 mum). The effects of drug particle size, the media pH and the core: wall ratio on the dissolution kinetics were studied, and evaluated kinetically.