The state of lipid peroxidation and antioxidants following thrombolytic therapy with rt-PA and streptokinase in acute myocardial infarction

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Ozmen D., Boydak B. , Mutaf I., Zoghi M. , Kumanlioglu K., Guner I., ...More

JAPANESE HEART JOURNAL, vol.40, no.3, pp.267-273, 1999 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 1999
  • Doi Number: 10.1536/jhj.40.267
  • Title of Journal : JAPANESE HEART JOURNAL
  • Page Numbers: pp.267-273


The role of reactive oxygen products in myocardial damage caused by ischemia-reperfusion has been established in a number of studies performed in animals models. However, studies showing the development of increased free radicals following effective myocardial reperfusion in humans are scarce. In the present study, both the increase of lipid peroxidation (LPO) following early stage thrombolytic therapy which is the current treatment issue performed after acute myocardial infarct (AMI) and the plasma levels of vitamin E and C (chain braker antioxidants) were investigated parallel to time.