In-vivo in vitro correlations of nitrofurantoin matrix tablet formulations


Karasulu H. Y. , ertan g., KOSE T. , GÜNERİ T.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, vol.21, no.1, pp.27-31, 1996 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 1996
  • Doi Number: 10.1007/bf03190275
  • Title of Journal : EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • Page Numbers: pp.27-31

Abstract

In our recent study, a new sustained release dosage form of nitrofurantoin (nft) as matrix tablets by 2(2) factorial design has been prepared by using different drug:polymer ratios. The effect of the polyvinylpyrolidone contents of nft matrix tablets on dissolution rate and bioavailability of the drug have been evaluated. The ideal formulation which fitted at USP XXII dissolution norms was tested by in vivo experiments. The satisfactory correlation was also obtained between the in vivo and the in vitro results.