is a well-known independent risk factor for CVD and metabolic syndrome. It has
been shown that moderate red wine consumption might reduce the risk of
cardiovascular disease (CVD). The aim of this study was to investigate whether
red wine has anti-inflammatory and antioxidative effect in overweight subjects.
Ten overweight and 14 healthy subjects drank 200 mL/day of red wine for one
month. While the Cabernet Sauvignon wine caused a significant increase in
paraoxonase activity (p<0.05), it led to a decrease in basal and stimulated
LDL diene levels in both of the groups (p<0.05). Total antioxidant activity
increased in the two groups following wine consumption. While wine consumption
had no effect on IL-6, TNF-alpha and CRP levels of overweight subjects, it led
to an increase in adiponectin levels.
Current data consider that regular red wine consumption may be beneficial to improve the antioxidant potential of LDL oxidation in overweight patients. In addition to the prevention of LDL oxidation, moderate wine consumption might delay the onset of atherosclerosis through an increase in paraoxonase and adiponectin levels.