Mortality reduction by post-dilution online-haemodiafiltration: a cause-specific analysis

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Nube M. J. , Peters S. A. E. , Blankestijn P. J. , Canaud B., Davenport A., Grooteman M. P. C. , ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.32, ss.548-555, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1093/ndt/gfw381
  • Sayfa Sayıları: ss.548-555


Background. From an individual participant data (IPD) meta-analysis from four randomized controlled trials comparing haemodialysis (HD) with post-dilution online-haemodiafiltration (ol-HDF), previously it appeared that HDF decreases all-cause mortality by 14% (95% confidence interval 25; 1) and fatal cardiovascular disease (CVD) by 23% (39; 3). Significant differences were not found for fatal infections and sudden death. So far, it is unclear, however, whether the reduced mortality risk of HDF is only due to a decrease in CVD events and if so, which CVD in particular is prevented, if compared with HD.