A Study Investigating the Role of 2 Candidate SNPs in Bax and Bcl-2 Genes in Alzheimer's Disease


ERDAL M. E. , GÖRÜCÜ YILMAZ Ş., Ay M. E. , GÜLER KARA H. , ÖZGE A., Tasdelen B.

PUERTO RICO HEALTH SCIENCES JOURNAL, vol.39, no.3, pp.264-269, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2020
  • Title of Journal : PUERTO RICO HEALTH SCIENCES JOURNAL
  • Page Numbers: pp.264-269

Abstract

Objective: The proto-oncogene Bax (Bcl-2-associated X protein) and related protein Bcl-2 (B-cell chronic lymphocytic leukemia/lymphoma-2) genes are triggers of apoptosis in Alzheimer's disease (AD). The balance of these proteins has an important role in the death or life of a neuronal cell, and the functional polymorphisms in genes expressing these proteins have been found to promote apoptosis. To investigate the role of Bax and Bcl-2 genes in AD, we examined the presence of the 2 polymorphisms in peripheral blood. To our knowledge, this is the first clinical association study of these 2 functional SNPs using the peripheral blood of patients with AD.