Multilocus Microsatellite Typing (MLMT) of Strains from Turkey and Cyprus Reveals a Novel Monophyletic L. donovani Sensu Lato Group


GOUZELOU E., HARALAMBOUS C., AMRO A., MENTIS A., PRATLONG F., DEDET J., ...Daha Fazla

PLOS NEGLECTED TROPICAL DISEASES, cilt.6, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: New foci of human CL caused by strains of the Leishmania donovani (L. donovani) complex have been recently described in Cyprus and the C, ukurova region in Turkey (L. infantum) situated 150 km north of Cyprus. Cypriot strains were typed by Multilocus Enzyme Electrophoresis (MLEE) using the Montpellier (MON) system as L. donovani zymodeme MON-37. However, multilocus microsatellite typing (MLMT) has shown that this zymodeme is paraphyletic; composed of distantly related genetic subgroups of different geographical origin. Consequently the origin of the Cypriot strains remained enigmatic.