PLGA encapsulation effect on Bioquin-HMPAO: radiolabeling and in vitro behaviour on brain and lung cancer cells


Kilcar A. Y. , Muftuler F. Z. , MEDİNE E. İ. , TEKİN V.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.310, ss.155-164, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 310 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10967-016-4746-0
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.155-164

Özet

Bioquin-HMPAO (BH) was previously investigated as a novel brain imaging agent by in vivo biodistribution studies. Present studies are carried out to explore radiolabeling and in vitro behaviour evaluation of poly (lactic-co-glycolic acid) (PLGA) encapsulated BH nanocapsules (BH-PLGA NCs). BH-PLGA NCs were characterized utilizing dynamic light scattering and scanning electron microscope. Encapsulation effect on radiolabeling with Tc-99m was examined by stability and lipophilicity studies and effect on in vitro behaviour of Tc-99m-BH was evaluated by incorporation studies on DAOY, U87-MG and A549 cells. It is observed that PLGA encapsulation has a positive and reinforcement effect.