Gingival crevicular fluid transforming growth factor-beta(1) in cyclosporine and tacrolimus treated renal transplant patients without gingival overgrowth


GUERKAN A., AFACAN B., EMINGIL F. , TOEZ H., BASKESEN A., Atilla G.

ARCHIVES OF ORAL BIOLOGY, vol.53, no.8, pp.723-728, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 8
  • Publication Date: 2008
  • Doi Number: 10.1016/j.archoralbio.2008.02.003
  • Title of Journal : ARCHIVES OF ORAL BIOLOGY
  • Page Numbers: pp.723-728

Abstract

Background: Gingival crevicular fluid (GCF) levels of transforming growth factor-P, (TGF-beta(1)) have been previously investigated in relation to the pathogenesis of cyclosporine-A (CsA)induced gingival overgrowth (GO) but no clinical data are available regarding the GCF levels of TGF-beta(1) in patients treated with tacrolimus (Tac). However, as gingival inflammation is pronounced at sites of GO and this consequently may lead to an elevation in TGF-beta(1) levels the present study aimed to evaluate gingival crevicular fluid (GCF) TGF-beta(1) levels in renal transplant patients using CsA or Tac without GO.