The aim of the present study is to examine the histological structure and to determine melanin-containing cells in liver for a better understanding of the role of these cells in Salamandra infraimmaculata. The surface of the liver is covered with haematopoietic tissue. The liver is divided into lobules. The boundaries between lobules are not clearly defined. Hepatocytes are radially arranged around the central vein. Melanin-containing cells are localised in the liver parenchyma. Although it is known that melanin-containing cells are present in various organs of heterothermic vertebrates such as kidney, liver, spleen and lung, their function in the visceral organs of lower vertebrates is still unclear.