Evaluation of infection imaging potential of I-131-labeled imidazolium salt


Tuncel A., Ocakoglu K., Colak S. G. , Yilmaz O., Ozturk I., Yurt F.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.315, no.3, pp.487-492, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 315 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.1007/s10967-017-5691-2
  • Title of Journal : JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Page Numbers: pp.487-492

Abstract

Effective antimicrobial compounds are necessary due to increased resistance of antibiotics against microorganisms causing infectious diseases. In this study, imidazolium-TFSI salt [ITFSI: octyl-bis(3-methylimidazolium)-di(bis(trifluoromethane)sulfonimide)] was labeled with I-131 with high efficiency. In vitro uptake experiments of I-131-ITFSI showed high uptake in gram-positive Staphylococcus aureus bacteria. I-131-ITFSI was also evaluated for comparison between bacterial infection and sterile inflammation by in vivo studies. The biodistribution results revealed that I-131-ITFSI might be used as a nuclear imaging agent for detection of bacterial infection.