Antifungal and Antibiofilm Activities of Selective Serotonin Reuptake Inhibitors Alone and in Combination with Fluconazole.

Tekintaş Y., Temel A., Ateş A., Eraç B., Metin D. Y. , Hilmioğlu Polat S. , ...More

Turkish journal of pharmaceutical sciences, vol.17, pp.667-672, 2020 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2019.65481
  • Title of Journal : Turkish journal of pharmaceutical sciences
  • Page Numbers: pp.667-672
  • Keywords: Candida spp., fluconazole, EUCAST, synergistic effect, antibiofilm, BIOFILM PRODUCTION, CANDIDA-ALBICANS, SERTRALINE, AGENTS


Objectives: Candida spp. are clinically important pathogens that cause difficulties for treatment by biofilm formation. Considering antifungal resistance rates and the limitations in the discovery of new antifungals, the antifungal and antibiofilm effects of various drugs used for different therapeutic purposes are becoming more important. The goal of our study was to determine the antifungal and antibiofilm effects of the selective serotonin reuptake inhibitors (SSRIs), namely sertraline (SRT), paroxetine (PRX), and fluoxetine (FLX) alone and in combination with fluconazole (FLC) against Candida spp.