IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine


Ciftdogan D. Y. , Onay H. , TOSUN S., Ozdemir T. R. , Ozkinay F. , Vardar F.

FUTURE VIROLOGY, vol.9, no.2, pp.123-130, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.2217/fvl.13.124
  • Title of Journal : FUTURE VIROLOGY
  • Page Numbers: pp.123-130
  • Keywords: child, gene polymorphism, hepatitisB, IFN-, interferon gamma, vaccine, TH2 CYTOKINE PRODUCTION, INTERFERON-GAMMA GENE, RECEPTOR 1 DEFICIENCY, VIRUS INFECTION, ANTIGEN, IMMUNOGENICITY, IMMUNIZATION, RISK, SUSCEPTIBILITY, REVACCINATION

Abstract

Aim: We investigated the +874 T/A polymorphism in the first intron of the IFNG gene and intronic (CA)(n) polymorphic microsatellite marker of the IFNGR1 gene in child nonresponders to hepatitisB vaccination. Materials & methods: A total of 100 children who had anti-HBs antibody levels <10 mIU/ml after vaccination against hepatitisB were included as a nonresponder group and 100 children who had anti-HBs antibody levels >10mIU/ml after vaccination against hepatitisB were included as a responder group. Results: The frequency of the TT genotype of the IFNG (+874 T/A) gene polymorphism was higher in nonresponders (p = 0.003). The frequencies of alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of IFNGR1 were significantly higher in nonresponders (for each, p<0.05). Conclusion: The TT genotype of the IFNG (+874 T/A) gene, and alleles 170 and 182 for (CA)(n) alleles for the intronic (CA)(n) microsatellite of the IFNGR1 gene, may be associated with nonresponse to hepatitisB vaccination.