Resveratrol Stimulates Hydrogen Sulfide (H2S) Formation to Relax Murine Corpus Cavernosum


Yetik-Anacak G. , DERELI M. V. , SEVİN G. , OZZAYIM O., ERAÇ Y. , Ahmed A.

JOURNAL OF SEXUAL MEDICINE, vol.12, no.10, pp.2004-2012, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.1111/jsm.12993
  • Title of Journal : JOURNAL OF SEXUAL MEDICINE
  • Page Numbers: pp.2004-2012

Abstract

IntroductionResveratrol (RVT) found in red wine protects against erectile dysfunction and relaxes penile tissue (corpus cavernosum) via a nitric oxide (NO) independent pathway. However, the mechanism remains to be elucidated. Hydrogen sulfide (H2S) is a potent vasodilator and neuromodulator generated in corpus cavernosum.