Matrix metalloproteinases (MMP-8 and-9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients

Atilla G. , Sorsa T., Ronka H., Emıngıl G.

JOURNAL OF PERIODONTOLOGY, cilt.72, ss.354-360, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 72
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1902/jop.2001.72.3.354
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Sayfa Sayıları: ss.354-360

Özet

Background: Gingival overgrowth (GO) is one of the most important side effects of cyclosporin A (CsA) medication, but its pathogenesis is not completely understood. The aim of this study was to identify and compare collagenase-2 (MMP-8), gelatinase-B (MMP-9), and neutrophil (PMN)-elastase levels in gingival crevicular fluid (GCF) from 15 renal transplant patients receiving CsA therapy and exhibiting CsA GO, 14 patients with gingivitis, and 10 periodontally healthy subjects.