YildirimE, Kormi I, Basoglu OK, Gurgun A, Kaval B, Sorsa T, Buduneli N. Periodontal health and serum, saliva matrix metalloproteinases in patients with mild chronic obstructive pulmonary disease. J Periodont Res 2013; 48: 269-275. (C) 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background and Objectives The present casecontrol study aimed to evaluate comparatively the salivary and serum levels of matrix metalloproteinases (MMP)-8 and- 13 and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with mild chronic obstructive pulmonary disease (COPD) and non-COPD controls. Material and Methods Clinical periodontal measurements were recorded before any periodontal intervention in 36 patients with mild COPD and 20 non-COPD controls admitted to Ege University Department of Chest Diseases COPD outpatient clinic (zmir, Turkey). Salivary and serum levels of MMP-8, MMP-13, and TIMP-1 were determined by immunofluorometric assay (IFMA) and enzyme-linked immunosorbent assay (ELISA). Data were analyzed with non-parametric statistical tests. Results Patients with COPD were significantly older than the control group (p<0.05). The COPD group showed significantly higher serum levels of MMP-8 IFMA, MMP-8/TIMP-1 IFMA than the control group (p<0.005). By ELISA, serum MMP-8, MMP-8/TIMP-1, TIMP-1, and MMP-13 levels were similar in both groups (p>0.05). Salivary MMP-8, MMP-13, and TIMP-1 levels were similar in both groups (p>0.05). Conclusions The present findings suggest that immunodetection of MMP-8 is dependent on the selected techniques and even with mild COPD some systemic inflammatory markers such as MMP-8 tend to increase. However, the present clinical periodontal and biochemical findings do not provide support for the previously proposed interaction between COPD and periodontal diseases.