(18)FDG conjugated magnetic nanoparticle probes: synthesis and in vitro investigations on MCF-7 breast cancer cells


OZKAYA F., ÜNAK P. , MEDİNE E. İ. , Sakarya S., UNAK G., TİMUR S.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.295, ss.1789-1796, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 295 Konu: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10967-012-2248-2
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.1789-1796

Özet

(18)FDG conjugated magnetic iron oxide nanoparticles (MNPs) were synthesized as PET-MR hybrid imaging agent. Synthesized and characterized NPs were then applied to MCF-7 human breast cancer cells. (18)FDG conjugated MNPs exhibited the cell incorporation ratio up to 30 %. As well as the characterization studies, apoptotic effects were observed depending on the cellular incorporations by the time. In conclusion, synthesized structures could have a potential as hybrid imaging agent in PET-MR imaging systems besides apoptotic effect on cancer cells.