The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada


Mente A., Chalcraft K., Ak H. , Davis A. D. , Lonn E., Miller R., ...Daha Fazla

CANADIAN JOURNAL OF CARDIOLOGY, cilt.31, ss.1189-1194, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 31 Konu: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.cjca.2015.06.016
  • Dergi Adı: CANADIAN JOURNAL OF CARDIOLOGY
  • Sayfa Sayıları: ss.1189-1194

Özet

Background: Microflora-dependent trimethylamine-N-oxide (TMAO) formation, which results from intake of choline and L-carnitine-rich food, shows promise as a predictor of cardiovascular disease (CVD) risk, but these associations have not been examined in ethnically diverse populations. In a multiethnic population-based study of adults in Canada, we assessed the stability of TMAO and L-carnitine in stored serum samples and their association with intimal medial thickness, prevalent risk factors, and clinical events.