The prevention of bone fractures after liver transplantation: Experience with alendronate treatment

ATAMAZ F. , Hepguler S. , Karasu Z. , KİLİC M. , TOKAT Y.

TRANSPLANTATION PROCEEDINGS, vol.38, no.5, pp.1448-1452, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2006
  • Doi Number: 10.1016/j.transproceed.2006.02.074
  • Page Numbers: pp.1448-1452


Objective. The aim of this study was to prevent fractures in the first postoperative year. Methods and patients. We studied 59 patients (48 men, 11 women) aged 42.6 +/- 11.4 years, who underwent liver transplantation. All patients received oral alendronate 70 mg weekly and calcium 1 g and calcitriol 0.5 mu g daily. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the lumbar spine and proximal femur at baseline as well as at 6 and 12 months after transplantation for comparison with an historical control group (n = 31). Spinal radiographs were obtained to assess vertebral fractures at the same time. Additionally, serum osteocalcin, serum parathyroid hormone (PTH), urinary deoxypyridinoline (DPD), and biochemical parameters were determined every 3 months.