Atorvastatin improves peritoneal sclerosis induced by hypertonic PD solution in rats


DUMAN S. , SEN S. , Sozmen E. , OREOPOULOS D.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, cilt.28, ss.170-176, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 2
  • Basım Tarihi: 2005
  • Dergi Adı: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
  • Sayfa Sayıları: ss.170-176

Özet

Background: Peritoneal sclerosis is a complication of peritoneal dialysis and results in ultrafiltration failure. It is related to chronic peritoneal injury due to dialysis solution content and recurrent peritonitis. Statins have anti-inflammatory properties which may be of value in modulating responses to injury. We evaluated the capacity of atorvastatin to modify peritoneal alterations secondary to hypertonic glucose.