Atorvastatin improves peritoneal sclerosis induced by hypertonic PD solution in rats


DUMAN S. , SEN S. , Sozmen E. , OREOPOULOS D.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol.28, no.2, pp.170-176, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2005
  • Title of Journal : INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
  • Page Numbers: pp.170-176

Abstract

Background: Peritoneal sclerosis is a complication of peritoneal dialysis and results in ultrafiltration failure. It is related to chronic peritoneal injury due to dialysis solution content and recurrent peritonitis. Statins have anti-inflammatory properties which may be of value in modulating responses to injury. We evaluated the capacity of atorvastatin to modify peritoneal alterations secondary to hypertonic glucose.