The effects of PPAR-gamma agonist pioglitazone on renal ischemia/reperfusion injury in rats


REEL B. , Guzeloglu M., Bagriyanik A., Atmaca S., Aykut K., Albayrak G., ...More

JOURNAL OF SURGICAL RESEARCH, vol.182, no.1, pp.176-184, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 182 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jss.2012.08.020
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.176-184
  • Keywords: Renal ischemia/reperfusion, PPAR-gamma agonist, MMP, Oxidative stress, Inflammation, ACTIVATED-RECEPTOR-GAMMA, ISCHEMIA-REPERFUSION INJURY, MATRIX METALLOPROTEINASES, ALPHA, REGULATOR, FAILURE, TARGETS, LIGAND, PROLIFERATION, INFLAMMATION

Abstract

Background: Acute renal failure due to renal ischemia/reperfusion (IR) injury is a significant clinical problem in cardiovascular surgery. Reactive oxygen species and inflammation play essential roles in the pathophysiology of IR injury. Matrix metalloproteinases (MMPs) are enzymes that play important roles in inflammation and mediate extracellular matrix degradation. It is known that peroxisome proliferatoreactivated receptor-gamma agonists have antiinflammatory and antioxidant effects. In the present study, we aimed to investigate the effects of pioglitazone, a synthetic peroxisome proliferatoreactivated receptor-gamma agonist, on MMPs and oxidative stress in a renal IR injury model in rats.