Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034


Aksoy S. C. , KÜÇÜKSOLAK M., UZEL A. , BEDİR E.

RECORDS OF NATURAL PRODUCTS, vol.15, no.6, pp.602-607, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.25135/rnp.203.20.08.1766
  • Title of Journal : RECORDS OF NATURAL PRODUCTS
  • Page Numbers: pp.602-607

Abstract

7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D-(H-1 and C-13 NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.