Effects of a lipoxygenase inhibitor on digoxin-induced cardiac arrhythmias in the isolated perfused guinea-pig heart

GOK S., Ulker S., Huseyinov A. , Evinc A.

GENERAL PHARMACOLOGY, vol.29, no.5, pp.789-792, 1997 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 1997
  • Doi Number: 10.1016/s0306-3623(97)00018-9
  • Title of Journal : GENERAL PHARMACOLOGY
  • Page Numbers: pp.789-792

Abstract

1. The effects of a lipoxygenase inhibitor, BW A4C, on digoxin-induced arrhythmias and cardiac dynamics (contractile force, perfussion pressure, heart rate) were investigated in Langendorff perfused isolated guinea pig hearts. In the control group, arrhythmias were induced by 25 mu g/ml digoxin at a perfusion rate of 0.5 ml/min. In the treated groups, BW A4C (1 and 0.3 mu M) perfused continuously from 15 min prior to digoxin until cardiac arrest occurred. Digoxin exposure (mu g/g wet weight of heart) for the occurrence of arrhythmias and cardiac arrest were the parameters evaluated to assess cardiotoxicity.