The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells


Cakir Z., SAYDAM G. , ŞAHİN F. , Baran Y.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.137, no.2, pp.279-286, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1007/s00432-010-0884-x
  • Title of Journal : JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Page Numbers: pp.279-286
  • Keywords: Ceramides, Bioactive sphingolipids, Resveratrol, Acute myeloid leukemia, HL60, ACUTE PROMYELOCYTIC LEUKEMIA, LONGEVITY-ASSURANCE GENE, GLUCOSYLCERAMIDE SYNTHASE, BREAST-CANCER, SPHINGOSINE KINASE, ANTITUMOR-ACTIVITY, CERAMIDE ANALOGS, FAMILY-MEMBERS, IN-VIVO, RESISTANCE

Abstract

Acute promyelocytic leukemia results from a translocation between 15 and 17 chromosomes that produce PML/RAR alpha fusion protein. PML/RAR alpha inhibits differentiation of myeloid precursor cells at stem cell level. Resveratrol is a phytoalexin that exerts cytotoxic effects on cancer cells. Ceramides have crucial roles in cell growth, proliferation, differentiation, drug resistance, and apoptosis. In this study, we examined the possible cytotoxic effects of resveratrol on acute myeloid leukemia cells and determined the roles of ceramide-metabolizing genes in resveratrol-induced apoptosis, in addition to investigating the possibility of increasing the sensitivity of HL60 cells to resveratrol by manipulating sphingolipids.