Chemical composition, antioxidant, anticholinesterase and anti-urease activities of Sideritis pisidica Boiss. & Heldr. endemic to Turkey


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Deveci E., TEL-CAYAN G., YILDIRIM H. , Duru M. E.

MARMARA PHARMACEUTICAL JOURNAL, cilt.21, ss.898-905, 2017 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 21 Konu: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.12991/mpj.2017.13
  • Dergi Adı: MARMARA PHARMACEUTICAL JOURNAL
  • Sayfa Sayıları: ss.898-905

Özet

The objective of this study was to investigate the chemical composition, antioxidant, anticholinesterase and anti-urease activities of essential oil, hexane, acetone and methanol extracts of Sideritis pisidica Boiss. & Heldr. The essential oil and fatty acid composition were analyzed by GC and GC/MS. delta-Cadinene (19.5 %), T-cadinol (16.7 %) and beta-cubebene (10.4 %) were identified as the main compounds of the essential oil whereas the most abundant compounds of fatty acids were found as linolenic (42.7 %), palmitic (31.3 %) and linoleic (13.4%) acids. The methanol extract demonstrated the highest antioxidant activity in all tests, except for metal chelating assay. The hexane extract was found to be significantly active in metal chelating (IC50 : 22.97 +/- 1.36 mu g/mL), acetylcholinesterase (62.54 +/- 0.88 %) and urease inhibitory (78.93 +/- 0.17 %) assays. These results show that the Sideritis pisidica could be used as the potential source of natural products in the food and pharmaceutical areas.