A sixty-two-year-old male patient underwent orchiectomy and was diagnosed with diffuse large B-cell lymphoma in the testicle and spermatic cord. F-18-FDG positron emission tomography/computed tomography (PET/CT) scanning was performed for initial staging. F-18-FDG PET/CT scan revealed multiple hyper-metabolic lymphadenopathies, lung lesions and mass lesions in the adrenal glands and kidneys. In addition, diffuse increased F-18-FDG uptake suggesting lymphomatous infiltration on the right testicle, prostate and left testicular veins were detected. The genitourinary system involvement is extremely rare in extranodal lymphomas and to the best of our knowledge this is the first case in the literature having F-18-FDG accumulating lesions in all genitourinary system structures.