Effect of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit


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USTUNES L., YASA M. , Kerry Z. , OZDEMIR N., BERKAN T., ERHAN Y., ...Daha Fazla

BRITISH JOURNAL OF PHARMACOLOGY, cilt.118, ss.1681-1688, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 118 Konu: 7
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1111/j.1476-5381.1996.tb15592.x
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.1681-1688

Özet

1 Intimal thickening is a common site for atherosclerosis. Therefore, we investigated whether the calcium entry blocker verapamil (10 mg kg(-1) body weight day(-1), s.c.) can retard intimal thickening and changes in vascular reactivity induced by a non-occlusive, silicone collar positioned around the left carotid artery of rabbits. The contralateral carotid artery was sham-operated and served as a control.