Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice


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Açıkgöz E. , AKTUĞ H. , YIGITTURK G., DEMIR K., GUVEN U., DUZAGAC F., ...Daha Fazla

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, cilt.55, ss.140-148, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 55 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5603/fhc.a2017.0014
  • Dergi Adı: FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
  • Sayfa Sayıları: ss.140-148

Özet

Introduction. Sunitinib is an oral inhibitor of vascular endothelial growth factor that is used to treat a variety of cancer. There are limited data regarding the effect of sunitinib on diabetes. In the liver, Notch signaling plays an important role in liver tissue development and homeostasis and its dysfunction is associated with liver pathologies. The aim of the present study is to investigate the effects of sunitinib on streptozotocin (STZ)-induced diabetic liver in mice models.