Photodynamic therapy and nuclear imaging activities of SubPhthalocyanine integrated TiO2 nanoparticles


Yurt F. , Sari F. A. , Ince M., Colak S. G. , Er O., Soylu H. M. , ...More

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, vol.367, pp.45-55, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 367
  • Publication Date: 2018
  • Doi Number: 10.1016/j.jphotochem.2018.08.004
  • Title of Journal : JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
  • Page Numbers: pp.45-55

Abstract

In this study, Subphthalocyanine (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc- TiO2) were examined as theranostic agents. In vitro photodynamic therapy (PDT) efficiency of SubPc/SubPc-TiO2 and nuclear imaging potential of I-131 labeled SubPc/TiO2-SubPc were determined on hepatocellular carcinoma (HepG2), colorectal adenocarcinoma (HT29) and human healthy lung (WI38) cell lines. As a result, I-131-SubPc and I-131-SubPc-TiO2 have been identified as a nuclear imaging agent for liver cancer. Additionally, I-131-SubPc-TiO2 has been found to be promising for imaging colon tumors. According to the in vitro photodynamic therapy studies, SubPc and SubPc-TiO2 were determined suitable PDT agents for liver and colon tumors. These results suggest that SubPc: TiO2 might be a theranostic agent with both PDT and nuclear imaging potential.