The aim of this study was to determine the utility of Tc-99(m)-tetrofosmin cardiac imaging in patients with previous myocardial infarction and with significant coronary artery disease (CAD) compared with that of Tl-201 cardiac imaging. Sixteen patients (14 males, 2 females) were studied by same-day exercise-rest Tc-99(m)-tetrofosmin imaging and exercise, rest and reinjection Tl-201 cardiac imaging. For each study, semiquantitative visual analysis was performed in 20 segments using a 4-point scale. The regional distribution and defect reversibility with the two tracers were compared with the results of coronary angiography. A total of 320 segments were analysed.