Nerve growth factor or IL-3 induces more IL-13 production from basophils of allergic subjects than from basophils of nonallergic subjects


Sin A. Z. , Roche E., Togias A., Lichtenstein L., Schroeder J.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.108, no.3, pp.387-393, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1067/mai.2001.117459
  • Title of Journal : JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Page Numbers: pp.387-393

Abstract

Background: Studies show that nerve growth factor (NGF) exhibits immunomodulatory activity. This neurotrophin is found at high levels in the serum of asthmatic individuals, is released during allergic reactions, and is reported to augment in vitro histamine and leukotriene C4 release by human basophils.