Renal cortical thickness and PON1 activity both decrease in chronic renal failure


AK G., OZGONUL M. , Sozmen E. , ASLAN S., SOZMEN B.

JOURNAL OF NEPHROLOGY, vol.15, no.2, pp.144-149, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2002
  • Title of Journal : JOURNAL OF NEPHROLOGY
  • Page Numbers: pp.144-149

Abstract

Background: Chronic renal failure (CRF) is associated with a tendency to atherosclerosis due to the enhanced oxidative stress and insufficient antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and paraoxonase (PON1), together with abnormalities in lipid parameters. We determined the in vitro susceptibility of low-density lipoprotein (LDL) to oxidation and PON1 activities in patients, with chronic renal insufficiency to see how PON1 affected the progression of the disease and whether hemodialysis influenced these parameters.