Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns


NALBANTOGLU S., TANYOLAC B., BERDELİ A.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, cilt.42, ss.159-162, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/03009742.2012.699551
  • Dergi Adı: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
  • Sayfa Sayıları: ss.159-162

Özet

Objectives: The inflammasome complex and the inflammatory pathway have been implicated in the pathogenesis of the most common autoinflammatory disorder, familial Mediterranean fever (FMF). Pyrin, the protein product of the FMF gene MEFV, interacts with the inflammasome complex adaptor protein ASC/PYCARD (apoptosis-associated speck-like protein with a CARD). Pyrin and ASC can both function as either inducers or suppressors of the cellular inflammatory response. We aimed to characterize ASC-induced gene expression profiles in FMF patients with different MEFV mutation patterns.