The effects of PPAR gamma agonist rosiglitazone on neointimal hyperplasia in rabbit carotid anastomosis model


Guzeloglu M., REEL B. , Atmaca S., Bagriyanik A., Hazan E.

JOURNAL OF CARDIOTHORACIC SURGERY, vol.7, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2012
  • Doi Number: 10.1186/1749-8090-7-57
  • Title of Journal : JOURNAL OF CARDIOTHORACIC SURGERY

Abstract

Background: Neointimal hyperplasia involving smooth muscle cell (SMC) proliferation, migration and extracellular matrix (ECM) degradation is an important component of atherosclerosis. It develops as a response to vascular injury after balloon angioplasty and vascular graft placement. Matrix metalloproteinases (MMPs) induce SMC proliferation, migration and contribute to intimal hyperplasia by degrading ECM. PPAR. agonists inhibit SMC proliferation, migration and lesion formation. In this study, we aimed to investigate the effects of PPAR. agonist rosiglitazone on neointimal hyperplasia and gelatinase (MMP-2 and MMP-9) expressions in rabbit carotid anastomosis model.