Effect of microemulsion formulation on biodistribution of <sup>99m</sup>Tc-Aprotinin in acute pancreatitis models induced rats.

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Ilem-Ozdemir D., Ustundag-Okur N., Senyigit Z. A. , Oruc N. , Asikoglu M., Ozutemiz O. , ...Daha Fazla

Drug delivery, cilt.23, ss.3055-3062, 2016 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/10717544.2016.1145306
  • Dergi Adı: Drug delivery
  • Sayfa Sayıları: ss.3055-3062


Background: Aprotinin is a monomeric globular polypeptide, which derived from bovine lung tissue and theoretically attractive molecule in ameliorating the effects of acute pancreatitis. Acute pancreatitis is an inflammatory condition of the pancreas that is painful and at times deadly. Over the following two decades Aprotinin therapeutic potential on pancreatitis is proven experimentally, its clinical therapeutic success is limited due to low targeting to pancreas.